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相关概念视频

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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相关实验视频

Updated: May 11, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

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多发性硬化症患者的维生素D水平和嗅觉功能障碍

Zidan Gao1, Zhuoma Danzhen2,3, Junyu Zhu2

  • 1School of Clinical Medicine, Soochow University, Suzhou, China.

The International journal of neuroscience
|February 19, 2024
PubMed
概括

血清维生素D水平可能会影响中国多发性硬化症 (MS) 患者的嗅觉功能障碍. 较低的维生素D与MS中较差的嗅觉功能相关,这表明潜在的调节作用.

关键词:
中国中国中国中国.多发性硬化症是多发性硬化症.嗅觉测试是一种嗅觉测试.宾夕法尼亚大学的气味识别测试测试.维生素D是维生素D的重要组成部分.

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相关实验视频

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科学领域:

  • 神经学 神经学
  • 内分泌学 在内分泌学.
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科

背景情况:

  • 多发性硬化症 (MS) 是一种慢性神经系统疾病.
  • 嗅觉功能障碍是MS中常见但经常被忽视的症状.
  • 维生素D在多发性硬化病原和症状中的作用是正在进行的研究领域.

研究的目的:

  • 研究多发性硬化症的中国患者血清维生素D水平与嗅觉障碍之间的关系.
  • 在MS患者和健康对照者之间比较嗅觉功能和维生素D水平.

主要方法:

  • 从中国贵州招募了25名多发性硬化患者和18名健康对照 (HC) 的队列.
  • 使用宾夕法尼亚大学气味识别测试 (UPSIT) 评估了嗅觉功能.
  • 测量了血清25-氧维生素D水平.

主要成果:

  • 在MS组和对照组之间观察到血清维生素D水平和UPSIT分数的显著差异 (p < 0.001).
  • 在MS患者的维生素D水平和UPSIT分数之间发现了显著的正相关性 (r = 0.537,p = 0.021).
  • 这表明,更高的维生素D水平与这种MS队列中更好的嗅觉功能有关.

结论:

  • 血清维生素D水平可能在中国贵州多发性硬化症患者中调节嗅觉功能障碍方面发挥作用.
  • 需要进一步的研究来阐明这种关联及其临床影响背后的机制.