多发性硬化症患者的维生素D水平和嗅觉功能障碍
Zidan Gao1, Zhuoma Danzhen2,3, Junyu Zhu2
1School of Clinical Medicine, Soochow University, Suzhou, China.
The International journal of neuroscience
|February 19, 2024
概括
血清维生素D水平可能会影响中国多发性硬化症 (MS) 患者的嗅觉功能障碍. 较低的维生素D与MS中较差的嗅觉功能相关,这表明潜在的调节作用.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病.
- 嗅觉功能障碍是MS中常见但经常被忽视的症状.
- 维生素D在多发性硬化病原和症状中的作用是正在进行的研究领域.
研究的目的:
- 研究多发性硬化症的中国患者血清维生素D水平与嗅觉障碍之间的关系.
- 在MS患者和健康对照者之间比较嗅觉功能和维生素D水平.
主要方法:
- 从中国贵州招募了25名多发性硬化患者和18名健康对照 (HC) 的队列.
- 使用宾夕法尼亚大学气味识别测试 (UPSIT) 评估了嗅觉功能.
- 测量了血清25-氧维生素D水平.
主要成果:
- 在MS组和对照组之间观察到血清维生素D水平和UPSIT分数的显著差异 (p < 0.001).
- 在MS患者的维生素D水平和UPSIT分数之间发现了显著的正相关性 (r = 0.537,p = 0.021).
- 这表明,更高的维生素D水平与这种MS队列中更好的嗅觉功能有关.
结论:
- 血清维生素D水平可能在中国贵州多发性硬化症患者中调节嗅觉功能障碍方面发挥作用.
- 需要进一步的研究来阐明这种关联及其临床影响背后的机制.
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