与艾滋病毒感染相关的全身性红斑狼:一个回顾性病例控制研究
Matthias Papo1, Julien Haroche2, Damien Sene3
1Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, Centre National de Référence pour le Lupus, le Syndrome des Anticorps Anti-phospholipides et Autres Maladies Auto-immunes Rares, Service de Médecine Interne 2, Institut E3M, Paris, France. matthias.papo@aphp.fr.
Clinical and experimental rheumatology
|February 19, 2024
概括
人体免疫缺陷病毒 (HIV) 患者的系统性红斑狼 (SLE) 很少见. 与没有艾滋病毒的患者相比,这些患者的病率和自身免疫细胞衰竭率增加.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 和人类免疫缺陷病毒 (HIV) 的同时发生很少被记录.
- 了解艾滋病毒感染者的SLE临床特征对于有效管理至关重要.
研究的目的:
- 在感染艾滋病毒 (SLE-PLHIV) 的患者中描述SLE.
- 将SLE在SLE-PLHIV中的表现与没有艾滋病毒感染的患者中的表现进行比较.
主要方法:
- 一项追溯病例控制研究,涉及13名在1975年至2020年期间被诊断出SLE-PLHIV的患者.
- 与年龄,性别和诊断年龄相匹配的SLE但没有艾滋病毒感染的患者进行比较,比例为 1:5.
主要成果:
- 对于SLE-PLHIV的SLE诊断时的中位数年龄为43岁,其中77%是女性.
- 常见的表现包括多关节炎 (84%),皮肤性狼 (69%) 和病 (54%).
- 与对照组相比,SLE-PLHIV表现出较高的脏表现频率 (54%vs. 16%) 和自身免疫细胞衰竭 (31%vs. 8%).
结论:
- 在SLE和艾滋病毒之间的联系是不常见的.
- 患有SLE-PLHIV的患者似乎经历了更大的脏干扰和自身免疫细胞衰竭的负担.
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