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视网膜血管密度下降与认知障碍有关在CADASIL:光学连贯性断层扫描血管学研究中:光学连贯性断层扫描血管学研究

Yu Guo^1,2, Jianchen Hao³, Ruilin Zhu³

¹Department of Neurology, Peking University First Hospital, Beijing, China.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|February 19, 2024

概括

在患有皮下心脏病发作和白内障病 (CADASIL) 患者的大脑自体主导动脉病的视网膜血管密度降低与MRI检测到的脑损伤和认知衰退相关. 光学连贯断层扫描血管学 (OCTA) 揭示了这些血管变化.

科学领域:

眼科医生眼科眼科
神经学神经学
血管生物学血管生物学

背景情况:

大脑自体主导动脉病变与下皮层心脏病发作和白脑病变 (CADASIL) 是一种影响大脑的遗传小血管疾病.
视网膜微血管结构的改变可能反映系统性血管病理,包括在CADASIL中.

研究的目的:

在CADASIL患者中评估视网膜血管密度的变化,使用光学连贯性断层扫描血管学 (OCTA).
研究这些视网膜血管变化与MRI发现 (损伤负担) 和CADASIL患者的认知功能之间的关联.

主要方法:

25名CADASIL患者和40名对照患者接受了OCTA (Cirrus HD-OCT 5000与AngioPlex) 测量斑点视网膜血管.
核磁共振扫描评估了病变负担,神经心理测试评估了认知功能.
部分斯皮尔曼等级相关性分析了OCTA参数,MRI和认知分数之间的关联.

主要成果:

与对照组相比,CADASIL患者的斑点血管密度和 perfusion 密度显著下降.
降低血管密度与法泽卡斯评分和MRI上的缺口心脏病发作有负相关性.
斑点血管密度和 perfusion 密度的降低与包括 MoCA 在内的认知测试的表现较差相关.

结论:

在CADASIL患者中,OCTA表明视网膜血管密度降低.
这些视网膜血管变化与MRI检测到的白质病变增加和认知障碍有关.
通过OCTA进行视网膜血管评估可以作为CADASIL中疾病严重程度的潜在指标.

关键词:

大脑自体主导动脉病变与皮层下心脏病发作和白细胞脑病变.认知认知是一种认知.磁共振成像技术磁共振成像技术光学连贯断层扫描扫描血管图谱.视网膜血管密度视网膜血管密度

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