在沙特阿拉伯地区的血红蛋白C的区域流行:一项流行病学调查
Mansour Aljabry1, Suha Sulimani2, Ghazi Alotaibi3
1Pathology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Maljabry@Ksu.edu.sa.
Journal of epidemiology and global health
|February 19, 2024
概括
血红蛋白C (HbC) 在沙特阿拉伯很少见,在麦加和麦地那地区的流行率较高. 这项研究分析了超过180万名婚前查参与者,以绘制HbC分布图.
科学领域:
- 血液学 血液学 血液学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 血红蛋白C (HbC) 是西非常见的一种血红蛋白病.
- 沙特阿拉伯的HbC的流行和分布没有得到充分的记录.
- HbC 疾病可能会导致轻度溶血性贫血,而与血红蛋白 S (HbS) 结合后会导致严重的表型.
研究的目的:
- 为了确定沙特阿拉伯HbC变种的区域流行率.
- 分析该地区最大的HbC流行病学研究数据.
- 评估从2011年到2018年接受婚前查的夫妇中的HbC患病率.
主要方法:
- 利用了婚前查和遗传咨询 (PMSGC) 计划的数据.
- 数据被收集并存储在SEHA电子存储库中,涵盖所有13个沙特地区.
- 血红蛋白电泳,包括HPLC和毛细血管电泳,用于确认HbC变体.
主要成果:
- 包括在2011年至2018年期间选的1,871,184名个人.
- 总共有778例 (0.04%) 的血红蛋白C被确定.
- HbC特征 (HbAC) 发生在764个个体中,罕见的同卵性HbC (HbCC) 和HbSC疾病. 红海附近的地区观察到更高的发病率.
结论:
- 血红蛋白C在沙特阿拉伯是一种罕见的变体,频率在区域上有显著差异.
- 麦加和麦地那地区显示HbC变种的流行率更高.
- 与HbS相比,HbC的独特地理分布解释了HbSC疾病的罕见性.
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