终身暴露于抑郁症和神经影像测量大脑结构和功能
Xinyi Wang1,2, Felix Hoffstaedter3,2, Jan Kasper3,2
1School of Biological Sciences and Medical Engineering, Child Development, and Learning Science, Key Laboratory of Ministry of Education, Southeast University, Nanjing, China.
JAMA network open
|February 19, 2024
概括
终身抑郁与持续的功能性大脑变化有关,更严格的诊断标准显示出更明显的变化. 这些发现可能解释了抑郁症研究中神经成像结果的变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 几十年来对抑郁症的神经成像研究显示出不一致的结果.
- 研究和元分析中的差异质疑抑郁症中观察到的大脑表型的稳定性.
研究的目的:
- 调查终身抑郁症暴露和神经成像测量六个操作标准之间的关联.
- 探索不同的抑郁症定义如何影响功能和结构性大脑变化.
主要方法:
- 使用英国生物库数据 (年龄在45-80岁之间) 的横截面研究.
- 包括终身抑郁症和匹配对照的人.
- 评估了六个抑郁症标准:寻求帮助,自我报告,抗抑郁药的使用,史密斯等人. 定义,ICD-10代码F32/F33,以及CIDI-SF分数. 这里可以查看.
- 评估的功能性措施 (fALFF,GCOR,LCOR) 和结构性措施 (GMV).
主要成果:
- 患有终身抑郁症的个体在所有标准上显示了fALFF,LCOR和GCOR的持续下降.
- 在灰色物质体积 (GMV) 中没有发现一致的变化.
- 医院ICD-10诊断代码 (F32/F33) 和抗抑郁药使用标准与最明显的功能变化有关.
结论:
- 终身抑郁症与强大的功能性大脑变化有关.
- 更严格的抑郁症定义显示出更明显的变化.
- 抑郁症纳入标准的变化可能解释神经成像文献中的不一致性.
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