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Updated: May 11, 2026

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通过2-Hydroxyphenol-pseudoproline (ψ2-hydroxyphenolpro) 进行"困难"的强有力的化学合成 修改

Xinyue Wang1, Kang Jin1

  • 1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

The Journal of organic chemistry
|February 19, 2024
PubMed
概括

研究人员开发了新的2-基-伪烯基构建块,以克服合成困难的挑战. 这些新的替代物 (ψ2-基) 能够有效地制备复杂的类药物.

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α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction01:15

α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction

The method to achieve α-brominated carboxylic acids using a mixture of phosphorus tribromide and bromine is known as the Hell–Volhard–Zelinski reaction. The reaction is catalyzed by phosphorus tribromide, which can be used directly or produced in situ from red phosphorus and bromine. The mechanism comprises PBr3 catalyzed conversion of acid to acid bromide and hydrogen bromide. The acid bromide enolizes to its enol form in the presence of HBr. The nucleophilic enol attacks the bromine molecule...