在电治疗期间增加弗卢马泽尼尔的有效性和安全性
Lennart Gistelinck1, Nele Van de Velde2, Hannelore Tandt2
1From the Department of Psychiatry, AZ Sint-Jan, Bruges.
富拉马泽尼尔是一种二类药物受体对抗剂,在电震治疗 (ECT) 期间适度增加了发作持续时间. 然而,它的临床影响是有限的,并且在ECT患者中,后触动仍然是令人担忧的.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 类药物可以在电治疗 (ECT) 期间对发作的质量和持续时间产生负面影响.
- 作为一种二氨酸受体对抗剂的弗卢马泽尼尔 (flumazenil) 已被提议用于减轻这些影响.
- 关于弗卢马泽尼尔在ECT中的疗效的临床证据有限.
研究的目的:
- 调查弗卢马泽尼尔对ECT期间发作持续时间的影响.
- 评估弗卢马塞尼尔对不良影响的影响,特别是后动的影响.
主要方法:
- 在ECT期间接受flumazenil的抑郁症患者的回顾性图表审查.
- 发作持续时间测量在flumazenil注射之前和之后.
- 通过使用标准化秤量来评估ECT的有效性;通过需要镇静剂或克制来确定 postictal agitation.
主要成果:
- 弗卢马泽尼尔的使用使脑电图的发作持续时间平均增加了10.5秒 (P = 0.003).
- 在21.8%的治疗中没有观察到发作持续时间的增加.
- 在ECT期间接受flumazenil的患者中,34.6%的患者出现了后节动作.
结论:
- 弗卢马泽尼尔在ECT中增加了发作持续时间,但临床意义有限.
- 在用弗卢马泽尼尔治疗的患者中观察到显著的后动的患病率.
- 临床医生应该考虑使用flumazenil在ECT中治疗短暂的发作之前,先考虑其他方法来降低发作值.
更多相关视频
09:07Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
10:23Equipment Setup and Artifact Removal for Simultaneous Electroencephalogram and Functional Magnetic Resonance Imaging for Clinical Review in Epilepsy
Published on: June 23, 2023
相关概念视频
Electroconvulsive Therapy
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Psychosis: Goals of Pharmacotherapy
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: Glutamate Antagonists
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
