卵白酸通过调节PI3K-AKT途径加速伤口愈合过程:转录和蛋白质组的联合分析
Huifang Ge1, Qi Yang2, Siwen Lyu2
1State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural University, Hefei 230036, P. R. China.
Journal of agricultural and food chemistry
|February 19, 2024
概括
卵白 (EWP) 通过减少炎症和促进生长因子来加速伤口愈合. 这项研究揭示了EWP.
科学领域:
- 生物医学科学 生物医学科学
- 皮肤病学 皮肤病学
- 再生医学是一种再生医学.
背景情况:
- 伤口愈合是一个复杂的,多阶段的生物过程.
- 市场对安全有效的伤口修复产品有很大的需求.
- 蛋白 (EWP) 显示出改善皮肤损伤的潜力,但其机制尚不清楚.
研究的目的:
- 研究卵白 (EWP) 加快伤口愈合的机制.
- 在全厚皮肤伤口模型中评估EWP的疗效.
- 为了确定参与EWP介导的伤口修复的分子途径.
主要方法:
- 使用全厚皮肤伤口模型来评估EWP的有效性.
- 用转录基因和蛋白质基因分析来阐明底层机制.
- 关键生长因子 (PDGF,VEGF,TGF-β1) 和炎症标志物被量化.
主要成果:
- 服用EWP显著降低了前炎性标志物,缩短了炎症阶段.
- 工业白皮肤加速了生长因子 (PDGF,VEGF,TGF-β1) 的分泌,增强了颗粒组织和内皮再生.
- 经过400mg/kg的EWP干预,在13天后,获得了90%的伤口愈合率.
- PI3K-AKT信号通路被确定为EWP伤口愈合效应中的核心网络.
结论:
- 卵白 (EWP) 显示出加速伤口愈合的巨大潜力.
- 脑电阻通过调节炎症反应和促进关键生长因子分泌来起作用.
- PI3K-AKT通路是EWP在伤口修复中的治疗效果的关键目标.
相关概念视频
Phases of Wound Repair
6.0K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.0K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
4.9K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
4.9K
Renewal of Skin Epidermal Stem Cells
2.5K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.5K


