油耗:通过稳定性分析对吉布斯表面热力学的见解
Shima Khodarahmi1, Fatemeh Eslami1, Leila Zargarzadeh2
1Department of Chemical Engineering, Tarbiat Modares University, Jalal Ale Ahmad Highway, P.O. Box 14115-111, Tehran, Iran.
Langmuir : the ACS journal of surfaces and colloids
|February 19, 2024
概括
脱油,或液体液相分离 (LLPS),可以在制药结晶过程中发生. 这项研究解释了水-瓦尼林系统中的脱油,表明它比晶体形成具有较低的能量屏障,但导致液滴不太稳定.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 物理化学 物理化学
- 结晶科学 结晶科学
背景情况:
- 结晶在制药中至关重要.
- 冷却结晶可以导致二次液相分离,称为"脱油"或液-液相分离 (LLPS).
研究的目的:
- 在二元水-瓦尼林系统中研究脱油现象.
- 使用吉布斯表面热力学和稳定性分析分析LLPS.
- 确定有利于滴滴与晶体形成的条件.
主要方法:
- 在稳定性分析中采用了吉布斯表面热力学.
- 研究了三个平衡情况:DLE,CL'E和CLE.
- 利用活动系数的NRTL模型绘制相位图.
- 在相位图上考虑的界面曲率效应.
主要成果:
- 与晶体形成相比,脱油的理由是液滴形成的能量障碍较低.
- 稳定的晶体比稳定的水滴具有明显较低的能量.
- 在基于超和的元稳定相图上定义了液滴和晶体形成的不同区域.
结论:
- 这项研究为了解制药结晶中的脱油提供了热力学基础.
- 确定了影响液-液相分离和结晶之间的竞争的关键因素.
- 为控制结晶过程提供了洞察力,以防止或促进脱油.
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