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发现和优化 (2-纳非) 乙酸衍生物作为选择性Bfl-1抑制剂

Pengpeng Niu1, Huiqi Xu2, Mengyang Fan3

  • 1Academy of Medical Engineering and Translational Medicine (AMT), Tianjin University, Tianjin 300072, China; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang 310018, China.

Bioorganic & medicinal chemistry letters
|February 19, 2024
PubMed
概括

研究人员开发了一种新型化合物,15,可以选择性地抑制抗亡蛋白B细胞淋巴瘤2 (Bcl-2) 家庭成员Bfl-1. 这种化合物通过向细胞存活至关重要的Bfl-1相互作用,显示出对癌症治疗的希望.

关键词:
(2-纳) 乙酸衍生物 (2-纳) 乙酸衍生物Bcl-2 抗亡蛋白质是一种抗亡蛋白.这是一种Bfl-1抑制剂.选择性的选择性全分析干扰化合物 (PAINS)

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