母亲营养和表观遗传编程对后代高血压的相互作用
You-Lin Tain1, Chien-Ning Hsu2
1Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
The Journal of nutritional biochemistry
|February 19, 2024
概括
母亲营养通过表观遗传变化影响后代高血压风险. 饮食干预可以提供保护性表观遗传修饰,以预防儿童的高血压.
科学领域:
- 发展生物学 发展生物学
- 营养科学 营养科学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 由于母亲的饮食因素,高血压可能起源于生命早期.
- 妊娠期间的营养不平衡可能会改变与血压相关的后代基因表达.
- 像DNA甲基化和microRNAs这样的表观遗传机制与高血压的发展有关.
研究的目的:
- 审查母亲营养不良如何影响胎儿高血压的编程.
- 探索表观遗传机制在后代高血压中的作用.
- 讨论饮食营养素和营养药物作为用于预防高血压的表观遗传修饰剂.
主要方法:
- 人类和动物研究的文献综述.
- 对关联孕产妇营养,表观遗传学和高血压的分子机制的分析.
- 讨论潜在的营养干预措施.
主要成果:
- 孕产妇营养不良可能导致胎儿通过表观遗传途径对高血压进行编程.
- 特定的营养素和化合物可以作为表观遗传修饰剂.
- 营养干预措施在抵消有害编程方面表现有前途.
结论:
- 母亲的饮食对于子女的长期心血管健康至关重要.
- 表观遗传修饰为高血压预防提供了治疗点.
- 需要进一步的研究来将营养策略转化为临床实践.
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