菌体治疗和当前的骨科感染的传递策略:一个广泛的审查
Jason Young1, Sang W Lee2, Mohammad J Shariyate3
1Harvard Combined Orthopedic Residency Program, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
The Journal of infection
|February 19, 2024
概括
细菌治疗对骨科感染有希望,最常见的是直接输送. 需要进一步的研究来优化这些难以治疗的疾病的剂量和输送方法.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 整形外科 整形外科 整形外科
背景情况:
- 菌体治疗正在成为对具有挑战性的感染的潜在辅助治疗方法.
- 菌体疗法对治疗难以治疗的感染产生了兴趣,特别是在最近几年.
- 缺少用于骨科感染的菌体剂量和输送的系统摘要.
研究的目的:
- 系统地总结骨科感染的菌体剂量和输送方法.
- 审查当前关于骨科感染的细菌治疗的证据.
- 识别有关骨科感染的菌体疗法的知识缺口.
主要方法:
- 根据PRISMA-ScR指南进行了范围审查.
- 在MEDLINE,Embase,Web of Science核心集合和Cochrane中央进行了搜索,直到2023年9月1日.
- 包括包括体外,动物和人类研究在内的研究.
主要成果:
- 包括77项研究:19项是体外,17项是动物和41项是人类研究.
- 直接菌体输送是最受研究的方法,特别是在假肢关节感染,骨髓炎和糖尿病足方面.
- 来自人类研究的证据表明,骨科感染的积极结果,尽管主要来自描述性研究.
结论:
- 直接菌体传递在骨科感染治疗中很普遍,特别是在假肢关节感染,骨髓炎和糖尿病足方面.
- 人类研究表明,菌体治疗在骨科感染中具有良好的结果,但证据质量通常较低.
- 限制包括需要了解最佳剂量,药理动力学,细菌异质性和菌体治疗毒性.
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