血清SGLT2的增加及其在急性缺血性中风患者的潜在诊断和预后价值
Yuhan Dong1, Bo Long1, Zhanglin Tian1
1Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, China.
Clinical biochemistry
|February 19, 2024
概括
在急性缺血性中风 (AIS) 患者中血清-葡萄糖共运输体-2 (SGLT2) 的水平升高,这表明它可能是诊断生物标志物. 然而,SGLT2水平与中风严重程度或患者长期结果无关.
科学领域:
- 神经学 神经学
- 生物化学 生化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 新出现的数据表明,-葡萄糖共运输体-2 (SGLT2) 是大脑缺血的潜在治疗标.
- 在急性缺血性中风 (AIS) 中SGLT2的作用仍未得到充分研究.
- 这项研究调查了AIS患者的SGLT2水平及其与功能预后的相关性.
研究的目的:
- 为了确定与健康对照组相比,急性缺血性中风 (AIS) 患者的血清SGLT2水平.
- 评估血清SGLT2水平与中风风险之间的关联.
- 评估血清SGLT2水平与AIS患者3个月功能结果之间的关系.
主要方法:
- 有望招募132名AIS患者和44名健康对照.
- 使用已确定的测定方法测量血清SGLT2水平.
- 后勤回归和ROC曲线分析以确定诊断和预测值.
主要成果:
- 血清SGLT2水平在AIS患者 (47.1 ng/mL) 中明显高于对照组 (35.7 ng/mL) (P=.000).
- 在SGLT2的切线值为39.55 ng/mL时,AIS诊断的灵敏度为90.2%,特异性为77.3%.
- 血清SGLT2水平与AIS发病时间有负相关性,但与NIHSS得分或病变体积没有关联.
- 在患者之间没有观察到SGLT2水平的显著差异,患者在3个月后的结果是有利的和不利的.
结论:
- 血清SGLT2度可能作为急性缺血性中风 (AIS) 的潜在诊断生物标志物.
- 在AIS患者中,SGLT2水平与疾病严重程度无关.
- 血清SGLT2度似乎不能预测AIS患者的功能预后.
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