晚期肺瘤患者的可治疗特征符合bronchoscopic肺体积减小与内支气管的条件
Rein Posthuma1, Marieke C van der Molen2, Jorine E Hartman2
1Department of Research and Development, Ciro+, Horn, the Netherlands; NUTRIM, School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht, the Netherlands; Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands.
Respiratory medicine
|February 19, 2024
概括
接受肺气内支气管治疗肺气的患者往往具有多种同时发生的可治疗特征. 更多可治疗的特征与这些患者更糟糕的健康相关生活质量相关.
科学领域:
- 肺部病理学 肺部病理学
- 呼吸系统医学 呼吸系统医学
- 临床试验 临床试验
背景情况:
- 使用内支气管 (EBV) 进行支气管镜肺体积减小 (BLVR) 符合条件的晚期肺患者表现出严重的静态肺膨胀,这是一个可治疗的特征.
- 在这个患者群体中,其他同时出现的可治疗特征 (TTs) 并未得到充分研究,它们对与健康相关的生活质量 (HRQL) 的影响也未得到充分研究.
研究的目的:
- 评估符合EBV治疗条件的COPD患者的TT频谱.
- 评估这些TT和HRQL之间的关联.
主要方法:
- 未来的,多中心的SoLVE研究 (NCT03474471) 评估了接受EBV的COPD患者的16个TTT.
- 使用圣乔治呼吸问卷 (SGRQ) 测量HRQL.
- 逻辑回归分析了TT和SGRQ分数之间的关系.
主要成果:
- 包括97名受试者,平均每名患者有8.1个TTT.
- 最常见的TT是体力活动较低 (95%),运动能力较差 (94%) 和严重疲劳 (75%).
- 更高的TT数量与较差的SGRQ总分数 (r=0.53;p<0.001) 有显著的关联,严重疲劳,抑郁和焦虑预测了更高的分数.
结论:
- 符合EBV资格的肺患者显示多重,同时发生的TT的高患病率.
- 增加的TT数量与该人群的HRQL下降有关.
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