使用扩展的非侵入性风险评分,包括常规脏生物化学,提高了异常葡萄糖耐受性的预测
Jie He1, Baoqi Fan1,2, Eric S H Lau1
1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
BMJ open diabetes research & care
|February 19, 2024
概括
改善糖尿病风险预测:采用常规生化学的新评分显著提高了异常葡萄糖耐受性个体的识别,有助于2型糖尿病预防工作.
科学领域:
- 内分泌学 在内分泌学.
- 预防医学 预防医学
- 生物统计学 生物统计学
背景情况:
- 在葡萄糖耐受性受损的个体中,2型糖尿病是可以预防的.
- 异常葡萄糖耐受性 (AGT) 在口服葡萄糖耐受性测试 (OGTT) 中通过2小时的血葡萄糖 (2hPG) 确定.
- 常规生物化学可以潜在地改善非侵入性糖尿病风险得分.
研究的目的:
- 通过整合常规生物化学来提高非侵入性糖尿病风险评分.
- 为了更有效地识别异常葡萄糖耐受性 (AGT) 个体.
- 帮助预防2型糖尿病.
主要方法:
- 利用了来自BHBHK-HKFDS队列 (1998-2003) 1938名参与者的基线数据.
- 将常规生物化学 (禁食血葡萄糖,血清,肌素,尿素) 纳入经过验证的非侵入性糖尿病风险评分.
- 使用接收器操作特征下的面积 (AUROC) 评估性能,并进行内部和外部验证.
主要成果:
- 最初的风险得分为0.698的AUROC,用于预测AGT.
- 扩展得分,包括常规生物化学,改善了AUROC至0.778 (p<0.001).
- 净重新分类改进总体为31.9%,表明预测准确度提高.
结论:
- 综合临床和常规生化学的扩展风险评分可以改善AGT的识别.
- 这种增强的分数可以集成到电子健康记录系统中.
- 促进针对高风险人群进行有针对性的OGTT评估,以预防糖尿病.
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