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在逐渐减少eculizumab的剂量时,应考虑到其药理动学的非线性

Olivier Le Tilly1,2, Philippe Gatault1,3, Saida Semlali2

  • 1Inserm U1327 ISCHEMIA "Membrane signalling and inflammation in reperfusion injuries", Université de Tours, Tours, France.

British journal of clinical pharmacology
|February 19, 2024
PubMed
概括

埃奎利祖马布表现出非线性药理动力学,这意味着其消除率随着度的变化而变化. 考虑到这种目标介导的消除对于优化脏疾病中的eculizumab剂量至关重要.

关键词:
剂量/反应关系关系在此之前,Eculizumab也曾被使用过.基于模型的精确剂量定量.这是一种单克隆抗体.非线性药理动力学 非线性药理动力学通过目标介导的处置.治疗药物监测 治疗药物监测

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