7天后早产婴儿的吸入氧化治疗:一个范围审查协议
Yohei Minamitani1, Shin Kato2, Miku Hosokawa3
1Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan yohei373@saitama-med.ac.jp.
BMJ open
|February 19, 2024
概括
本范围审查审查检查了临床和回声发现,以启动吸入氧化 (iNO) 在早产婴儿后急性阶段. 它旨在标准化对新生儿的非标签iNO使用的标准.
科学领域:
- 新生儿医学 新生儿医学
- 呼吸系统生理学 呼吸系统生理学
- 儿童心脏病学 儿童心脏病学
背景情况:
- 吸入的氧化 (iNO) 是在期末/晚期早产婴儿中持续性肺高血压的标准.
- 标签外的iNO使用在早产婴儿 (7天后) 中增加,用于预防或救助支气管肺功能障碍症 (BPD).
- 目前对于早产婴儿的后急性期iNO治疗的启动标准不一致.
研究的目的:
- 确定和总结用于在后急性阶段在早产婴儿中启动吸入氧化 (iNO) 治疗的临床和心声学发现.
- 为在这个弱势群体中制定标准化的iNO启动标准提供基础.
主要方法:
- 根据PRISMA-ScR指南进行范围审查方法.
- 对PubMed,Embase和Ichushi数据库进行系统的文献搜索 (2003年1月 - 2023年8月).
- 包括RCT,队列研究,病例控制研究和iNO在早产婴儿后急性阶段的病例系列.
主要成果:
- 数据提取和研究特征和报告结果的总结.
- 确定影响iNO启动决策的各种临床和心声学参数.
- 关于iNO在后急性早产婴儿中使用的现有实践的综合证据.
结论:
- 在临床和心声学标准中存在显著的变化,用于在后急性阶段在早产婴儿中启动吸入氧化 (iNO).
- 需要进行进一步的研究和达成共识,以便为这种非标签iNO应用程序制定标准化指南.
- 标准化标准可以优化早产新生儿与BPD相关并发症的iNO治疗的有效性和安全性.
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