在糖尿病小鼠中,Troxerutin通过调节微生物组成和肠道屏障功能来改善海马体中的认知功能和分叉盒F2表达
1Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
概括
托克塞鲁丁通过增强肠道微生物群和血脑屏障 (BBB) 来改善糖尿病认知功能障碍. 这种治疗增加了大脑中的分叉盒F2 (FOXF2),表明肠-大脑轴连接.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肠道微生物影响血脑屏障 (BBB) 的完整性.
- 糖尿病认知功能障碍 (DCD) 是一个日益关注的问题.
- 肠道微生物群在DCD中的作用和潜在的治疗点需要进一步研究.
研究的目的:
- 为了研究肠道微生物和框F2 (FOXF2) 之间的关系.
- 阐明troxerutin改善糖尿病认知功能障碍 (DCD) 的机制.
主要方法:
- 糖尿病小鼠接受了托克塞鲁丁治疗,持续了8周.
- 用莫里斯水迷宫 (MWM) 和新型物体识别 (NOR) 任务来评估认知功能.
- 分析了肠道微生物组成,短链脂肪酸 (SCFA),肠道屏障功能和海马FOXF2表达.
主要成果:
- 托克塞鲁丁改善了糖尿病小鼠的认知功能.
- 它调节了肠道微生物群的组成,增加了细菌菌的丰富性和SCFA水平 (propionic和黄油酸).
- 托克塞鲁丁增强了肠道屏障的完整性,并提高了海马FOXF2表达的调节,而抗生素治疗可以减弱这种表达.
结论:
- 托克塞鲁丁通过对海马FOXF2表达的上调调节来改善DCD.
- 这种效果是通过调节肠道微生物组成和改善肠道屏障功能来实现的.
- 这些发现突出了肠-大脑轴作为DDC的治疗点.
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