艾滋病毒感染患者的维生素D缺乏和口腔候群病:一个病例控制研究
Shabnam Tehrani1,2, Ladan Abbasian3, Seyed Ali Dehghan Manshadi4
1Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.
BMC infectious diseases
|February 19, 2024
概括
维生素D缺乏症在艾滋病毒患者中很常见,并且与口腔候群病有关. 补充剂可以改善口腔健康和预防感染在这个人群.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 口腔角膜炎是人类免疫缺陷病毒 (HIV) 感染个体的常见机会性感染.
- 很大一部分感染艾滋病毒的患者也缺乏维生素D.
- 这项研究调查了艾滋病毒患者的维生素D水平和口腔候群病之间的关系.
研究的目的:
- 确定血清25-基维生素D水平与艾滋病毒感染患者口腔候群病的存在之间的关联.
- 为了比较维生素D水平,CD4计数和艾滋病毒患者之间的病毒载量,有和没有口腔候群病.
主要方法:
- 一项病例控制研究,涉及104名艾滋病毒感染口腔候群病患者 (病例) 和102名年龄和性别匹配的艾滋病毒感染患者没有口腔候群病 (对照).
- 测量了所有参与者的血清25-氧维生素D水平,CD4计数和病毒载量.
- 统计分析,包括多变量逻辑回归,以确定与口腔候群病相关的因素.
主要成果:
- 这些病例表现出显著较低的25-基维生素D水平 (平均差异 = 33.86 ng/mL) 和CD4计数 (平均差异 = 267.48细胞/mm3).
- 与对照组相比,病例的病毒载量也显著增加 (平均差异 = 7.03 × 105副本/毫升).
- 多变量分析表明,较低的教育状况,当前的HAART,先前的口腔候群病,较低的CD4计数,较高的病毒载量和较低的维生素D水平与口腔候群病风险增加有显著关联.
结论:
- 维生素D缺乏症 (维生素D缺乏症) 在艾滋病毒感染者中普遍存在,特别是那些患有口腔候群病的人.
- 低维生素D水平与艾滋病毒患者患口腔候群病的风险增加显著相关.
- 补充维生素D可能是一个有益的策略,以提高口腔健康和预防艾滋病毒阳性人群的口腔候群病.
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