与美国人口尿失禁相关的尿和暴露
Jinjiang Jiang1, Bo Chen1, Bo Tang1
1Department of Urology, Institute of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu, Sichuan, China.
BMC public health
|February 19, 2024
概括
暴露于双甲 (BPA),triclosan (TCS) 和benzophenone-3 (BP-3) 可能会增加患尿失禁 (UI) 的风险. 这项研究分析了大量人口样本中常见的个人护理产品化学物质及其与UI的关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 个人护理产品 (PCP) 含有可在尿液中检测到的 (PNs) 和类 (PBs).
- 尿失禁 (UI) 是一种普遍的疾病,有多因素的原因.
- 与PCP相关的化学物质对UI风险的潜在影响尚未完全理解.
研究的目的:
- 调查与PCP相关的特定类和类在尿中的度与尿失禁的发生之间的关联.
- 检查这些协会在一般人群中,特别是在女性人口统计学中.
- 用先进的统计建模来评估化学混合物对UI的影响.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2007-2016) 的横截面分析.
- 包括7690名自我报告UI诊断 (SUI,UUI,MUI) 的参与者.
- 应用回归分析和贝叶斯核机回归 (BKMR) 来评估暴露混合物.
主要成果:
- 相-3 (BP-3) 暴露与压力尿失禁 (SUI) 有积极关联.
- 双甲 (BPA) 暴露与急性尿失禁 (UUI) 和混合尿失禁 (MUI) 的风险增加相关.
- 特里克洛桑 (TCS) 暴露与 MUI 呈现负相关性;并没有发现对类药物的显著联系.
结论:
- 尿中的双甲 (BPA),三三 (TCS) 和三 (BP-3) 度可能与尿失禁风险增加有关.
- 像BPA和BP-3这样的特定化学物质与不同类型的UI表现出明显的关联.
- 需要进一步的研究来阐明这些发现的机制和临床影响.
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