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Updated: Jul 2, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

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一种短暂的蛋白质折叠反应在TDP-43介导的神经退行症的早期阶段针对聚合

Rebecca San Gil1, Dana Pascovici2,3, Juliana Venturato1

  • 1Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.

Nature communications
|February 19, 2024
PubMed
概括

研究人员绘制了肌缩侧面硬化症 (ALS) 和前叶退化症 (FTLD) 的小鼠模型中的蛋白质变化. 他们发现,像DNAJB5这样的蛋白质折叠因子可能会防止神经退行,提供新的治疗点.

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Published on: January 2, 2015

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Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

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