冠状动脉体调节失调有助于长期COVID症状
Ahmed El-Medany1,2,3, Zoe H Adams1, Hazel C Blythe1
1School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
长期COVID患者表现出较高的动脉化学反射灵敏度,这可能解释了他们的呼吸和运动问题. 这种过敏性可能是未来长期COVID治疗的目标.
科学领域:
- 心血管呼吸系统生理学
- 神经科学是一个神经科学.
- 传染病病理学 传染病病理学
背景情况:
- 长期COVID呈现出疲劳和运动不耐受等衰弱症状,其潜在机制尚不清楚.
- 这些症状与心力衰竭重叠,并且可能涉及动脉化学反射敏感度增加.
- 动脉体的高ACE2表达,SARS-CoV-2的入口点,促使人们对其在长期COVID中的作用进行调查.
研究的目的:
- 调查长期COVID的个体是否会增加带化学反射敏感度.
- 在长期的COVID中探索带化学反射敏感性和呼吸失调和运动不耐受症的症状之间的关系.
主要方法:
- 在14名未住院的长期COVID参与者和14名对照者之间,比较了低氧呼吸反应 (HVR),这是一种测量心动脉化学反射灵敏度的尺度.
- 使用心肺运动测试来评估呼吸效率 (VE/VCO2斜率).
- 采用了统计分析,包括学生的未配对t测试,ANOVA和皮尔森的相关系数.
主要成果:
- 长期COVID参与者在运动期间显示出明显更高的VE/VCO2斜率,这表明过度高通风.
- 与对照组相比,长期COVID组的低氧呼吸反应 (HVR) 显著增加.
- 在HVR和VE/VCO2斜率之间发现了显著的负相关性,这表明动脉体过敏性有助于高通风.
结论:
- 冠状动脉化学反射敏感性在长期COVID中很明显,可能是潜在的呼吸失调和运动不耐受.
- 准 carotid 身体兴奋度为管理长期COVID 症状提供了一个潜在的治疗策略.
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