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Updated: Jul 2, 2025

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

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多式联络CNN-DDI:使用多式联络CNN来检测与药物相互作用相关的事件

Muhammad Asfand-E-Yar1, Qadeer Hashir1, Asghar Ali Shah2

  • 1Department of Computer Science, CoE-AI, Center of Excellence Artificial Intelligence, Bahria University, Islamabad, Pakistan.

Scientific reports
|February 20, 2024
PubMed
概括

本研究引入了一种多模式卷积神经网络 (MCNN-DDI) 模型,用于预测药物对药物相互作用 (DDI). 该模型通过整合化学结构,点和酶来实现90%的准确性,以提高DDI事件预测.

关键词:
人工智能的人工智能卷积神经网络 (CNN) 是一种神经网络.药物 药物 药物 是一种药物.机器学习模型 机器学习模型神经网络的神经网络的神经网络

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Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
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Drug-Receptor Interaction: Antagonist01:28

Drug-Receptor Interaction: Antagonist

An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
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Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
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