一种基于omics的机器学习方法来预测糖尿病的进展:RHAPSODY研究.
Roderick C Slieker1,2,3,4, Magnus Münch1, Louise A Donnelly5
1Department of Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Diabetologia
|February 20, 2024
概括
通过使用临床因素和分子标记物,可以预测2型糖尿病中的胰岛素启动. 机器学习模型表明,添加蛋白质和代谢物适度地提高了更快疾病进展的预测准确性.
科学领域:
- 内分泌学和新陈代谢学
- 计算生物学 计算生物学
- 生物标志物发现发现
背景情况:
- 2型糖尿病的进展是异质的,胰岛素发射率各不相同.
- 像HbA1c和年龄这样的经典生物标志物可以预测血糖进展,但它们预测胰岛素开始的能力尚不清楚.
- 新型分子标志物对胰岛素需求的附加预测价值尚不清楚.
研究的目的:
- 调查临床变量和分子标记物 (代谢物,脂质,蛋白质) 的预测价值,用于2型糖尿病中胰岛素需求的时间.
- 为了比较不同的机器学习方法在预测胰岛素启动方面的性能.
- 为了确定分子标记物是否能改善超越已确定的临床因素的预测.
主要方法:
- 分析了两个前性队列 (IMI-RHAPSODY研究),包括585名 (DCS) 和571名 (GoDARTS) 个人.
- 机器学习模型 (拉索,,GRridge,随机森林) 用于预测胰岛素需求的时间.
- 模型包含了临床变量 (年龄,性别,HbA1c,HDL胆固醇,C) 和分子标记物 (代谢物,脂质,蛋白质).
- 用哈雷尔的C统计学来评估模型的性能.
主要成果:
- 在预测模型中经常选择临床变量,特别是HbA1c,年龄和C-.
- 具有临床变量的基准模型显示了中等的预测性能 (C-统计~0.71).
- 包括HDL-胆固醇和C-改善了模型的性能.
- 两种蛋白质,乳腺素和原生基因氨酸蛋白激酶受体,被一致选择并略微提高了预测.
结论:
- 机器学习模型可以适度预测2型糖尿病的胰岛素需求风险,主要使用临床变量.
- 纳入分子标记物,特别是蛋白质,可以提高预后性能高达5%.
- 这些预测模型可以帮助识别患有2型糖尿病的个体,他们面临更高风险的疾病进展迅速,需要加强治疗.
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