低剂量托利的消除特征及其在头发中的检测用于兴奋剂分析 - - 对无意的非治疗性暴露的影响
Detlef Thieme1, Kai Weigel1, Patricia Anielski1
1Institute of Doping Analysis and Sports Biochemistry Dresden, Kreischa, Germany.
Drug testing and analysis
|February 20, 2024
概括
允许药物中的甲 (CLT) 污染可能导致运动员无意中违反兴奋剂规则. 这项研究发现,CLT清除速度较慢,毛发的结合率较高,这表明从微量污染中可能出现不良分析结果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 运动科学 运动科学 运动科学
- 分析化学 分析化学
背景情况:
- 塔利 (CLT) 是一种用于治疗和高血压的利尿剂.
- 导尿剂被WADA禁止,其中一些因污染而达到20 ng/mL的门.
- 最近的一起案件质疑来自其他药物中CLT污染的无意中兴奋剂.
研究的目的:
- 通过CLT污染调查非故意兴奋剂的可能性.
- 为了分析CLT和甲 (HCTA) 在尿液和头发中的共排泄.
- 评估低剂量CLT摄入造成不良分析结果的风险.
主要方法:
- 低剂量的CLT和HCTA同时给两名志愿者服用,持续5天.
- 使用液体染色学-并联质谱法 (LC-MS/MS) 分析尿样.
- 检查了CLT在头皮毛发中的结合.
主要成果:
- 在高度的尿液中,HCTA迅速排出.
- 临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床
- 当与HCTA同时使用时,在头发中观察到更高的CLT整合.
结论:
- 由于污染导致的亚治疗性CLT摄入可能会导致不良的分析结果.
- 较慢的CLT消除和毛发结合突出显示了运动员的风险.
- 这项研究对于了解兴奋剂控制和无意违规行为至关重要.
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