阴道可以是克罗恩病的预兆吗? 一个案例系列
Sandra Rios Melendez1, Aldo Majluta1, Annette Medina2
1PGY-3, Pediatric Residency Program, Nicklaus Children's Hospital, Miami, Florida, USA.
Journal of pediatric gastroenterology and nutrition
|February 20, 2024
概括
腹腔克罗恩病 (VCD) 可以在胃肠道症状出现之前表现出来,使诊断复杂化. 早期识别和治疗,通常是用生物药物,如因弗利西马布,对于管理这种罕见的肠外表现是至关重要的.
科学领域:
- 胃肠病学 胃肠病学
- 皮肤病学 皮肤病学
- 儿科 儿科 儿科
背景情况:
- 腹腔克罗恩病 (VCD) 是克罗恩病 (CD) 的一种罕见的肠外表现.
- 诊断VCD可能具有挑战性,因为部症状可能会先于胃肠道表现.
- 早期诊断和管理对于儿科患者至关重要.
研究的目的:
- 描述儿科患者VCD的临床表现,放射学发现和治疗结果.
- 突出与VCD相关的诊断挑战,特别是当它在GI症状之前时.
- 评估生物疗法在治疗VCD方面的有效性.
主要方法:
- 五名被诊断患有VCD的儿科女性患者的回顾性审查.
- 分析诊断的时间,出现症状和放射性发现 (MRI).
- 评估胃肠道疾病的严重程度 (巴黎分类) 和治疗反应.
主要成果:
- 所有的患者在MRI上都表现出 vulvar 炎症.
- 两名患者出现了胃肠道疾病之前的阴道症状,导致诊断延迟.
- 所有患者在结肠镜检查时都有活跃的疾病;三个患者有显著的结肠直肠炎症.
- 四名患者对infliximab反应良好,一名患者对ustekinumab反应良好.
结论:
- 腹腔克罗恩病可能会在胃肠道症状出现之前出现,导致误诊和延迟治疗.
- 磁共振成像对于诊断CD. vulva炎症非常有价值.
- 诸如infliximab和ustekinumab之类的生物疗法在VCD管理中有效.
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