[合成化合物扰乱脂质代谢并诱导肥胖效应]
Hui-Nan Liu1,2, Zhen-Dong Sun3, Qian Liu1
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Se pu = Chinese journal of chromatography
|February 20, 2024
概括
环境中的化学物质被称为肥胖原体,破坏脂质代谢,导致肥胖. 在日常产品中发现的合成化合物 (SPC) 是影响脂肪生成和脂质储存的关键肥胖原体.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 肥胖是一个全球性流行病,与遗传,饮食和环境因素有关.
- 环境肥胖原体是破坏脂质代谢并促进肥胖的化学物质.
- 合成化合物 (SPC) 在消费品中普遍存在,并带来暴露风险.
研究的目的:
- 审查选环境肥胖原体的方法.
- 系统地讨论三种类型的SPCs的肥胖效应:双A (BPA) 和它的类似物,基 (AP) 和合成性抗氧化剂 (SPA).
- 阐明SPC产生的肥胖效应背后的毒理机制.
主要方法:
- 三种常见的查方法的摘要和比较:体外分子相互作用试验,细胞脂肪生成差异化模型和体内脂质代谢研究.
- 对SPC对脂肪生成和脂质代谢的影响的体外和体内数据的系统审查.
- 讨论毒理机制,包括核受体转活,炎症,氧化应激,肠道微环境和表观遗传修饰.
主要成果:
- 包括BPA类似物,AP和SPA在内的SPC干扰脂肪生成和脂质代谢.
- 这些化合物影响脂肪组织中的脂质储存和肝脏中的脂质积累,可能导致肝脏肥胖症.
- 观察到的效应与诸如改变核受体活性,炎症,氧化应激和表观遗传变化等机制有关.
结论:
- 产品简介表现出肥胖性质,影响脂质代谢,并导致健康问题.
- 了解SPC的结构-活动关系对于风险评估至关重要.
- 需要对新兴肥胖化学物质进行进一步的研究,以告知公共卫生战略.
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