在接受息治疗的癌症患者中与长期存活相关的因素:一项探索性研究
José António Ferraz-Gonçalves1,2, Adelaide Alves3, Álvaro José Silva1,4
1Faculty of Medicine, Porto University, Porto, Portugal.
Journal of palliative care
|February 20, 2024
概括
在接受息治疗的癌症患者中,确定延长生存的因素至关重要. 更高的血红蛋白和肌素水平与更长的生存时间有关,而疼痛和表现不佳的状态表明预后更短.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 一些癌症患者在接受息治疗后经历了长时间的生存 (≥1年).
- 确定预后因素对于个性化护理规划至关重要.
研究的目的:
- 确定在接受息治疗的癌症患者中与延长生存相关的因素.
- 为了比较长期幸存者的特征与短期幸存者的特征.
主要方法:
- 使用电子健康记录进行的回顾性病例控制研究 (2012-2018).
- 将生存时间≥1年 (病例) 的患者与生存时间≤6个月 (对照组) 的患者进行比较.
- 多变量分析以确定显著的预后因素.
主要成果:
- 分析了111例 (6.4%) 和363例 (21.1%) 的对照.
- 较高的血红蛋白 (≥10.6 g/dL) 和肌素 (>95 μmol/L) 与更长的生存时间相关.
- 异常的认知,疼痛,厌食症,肝转移,ECOG状态>1,高中性粒细胞/淋巴细胞比率 (≥3.43) 与较短的存活时间有关.
结论:
- 几种临床和实验室因素显著预测了息护理癌症患者的长期存活.
- 发现需要在更大规模的前性研究中进行验证,以获得临床应用.
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