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抑郁症,血管负担和痴呆症在中年晚期和老年黑人成年人中的患病率
Shellie-Anne Levy1,2, Maria B Misiura3, Jeremy G Grant1
1Department of Clinical and Health Psychology, The Center for Cognitive Aging and Memory, University of Florida, Gainesville, Florida, USA.
概括
晚年抑郁症和白质强度过高 (WMH) 会增加痴呆风险,特别是在黑人成年人中. 患有抑郁症和高WMH体积的个体表现出最高的痴呆症患病率.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 晚年抑郁症和白质强度过高 (WMH) 与痴呆症风险增加有关.
- 对黑人成年人这些关联的研究是有限的.
研究的目的:
- 调查抑郁症和WMH体积与老年黑人成年人痴呆风险的关联.
- 为了检查抑郁症和WMH体积的组合是否会加剧痴呆症风险.
主要方法:
- 来自国家阿尔茨海默氏症协调中心统一数据集的55岁以上的443名黑人参与者的二次数据分析.
- 奇方位和后勤回归分析控制人口和血管因素.
主要成果:
- 抑郁症和更高的WMH体积都与更高的痴呆症患病率独立相关.
- 患有痴呆症的风险在患有抑郁症和高WMH体积的人群中最高.
- 与非西班牙裔白人成年人相比,黑人成年人中抑郁症/WMH和痴呆症之间的关联更强.
结论:
- 晚年抑郁症和WMH对痴呆风险有独立和联合的影响.
- 由于这些因素,黑人可能面临特别高的风险.
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