治疗抑郁症的Vortioxetine在患有Prodromal与轻度阿尔茨海默氏病的患者:一个为期六个月的,开放标签,观察性研究
A Padovani1, S Caratozzolo, A Benussi
1Alessandro Padovani, Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy, Piazzale Spedali CIvili 1, 25123, Brescia, Italy, alessandro.padovani@unibs.it, Tel: +390303995632.
The journal of prevention of Alzheimer's disease
|February 20, 2024
概括
沃尔提奥谢有效治疗阿尔茨海默氏症中的抑郁症.
科学领域:
- 神经科学和精神病学 在
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抑郁症状在阿尔茨海默病 (AD) 中很普遍,即使在早期阶段也是如此.
- 此前对AD痴呆症抗抑郁药物的研究已经产生了混合的结果.
- 了解AD不同阶段的治疗疗效至关重要.
研究的目的:
- 为了比较vortioxetine在患有抑郁症的前兆性和轻度至中度AD患者的疗效.
- 评估西对行为障碍,认知功能和日常生活活动的影响.
- 为了确定与治疗反应相关的因素.
主要方法:
- 对89名阿尔茨海默病患者进行了回顾性分析,这些患者接受了西治疗,并进行了6个月的随访.
- 标准化的评估包括迷你精神状态检查 (MMSE),老年抑郁症量表 (GDS) 和神经精神科目录 (NPI).
- 用重复测量多变量分析和线性回归来分析变化和相关因素.
主要成果:
- 西显著改善了GDS,NPI得分 (情绪,焦虑,冷漠,睡眠,饮食) 和MMSE得分.
- 预发性和轻度至中度的阿兹海默症患者都显示出积极的GDS反应.
- 轻度至中度的AD患者在NPI和特定的行为子项目中表现出更大的改善;前期的AD显示出更大的MMSE改善.
结论:
- 沃尔提奥塞丁耐受性良好,有效治疗前兆性和轻度至中度AD的抑郁症.
- 轻度至中度AD患者在行为障碍方面经历了更广泛的好处.
- 观察到显著的认知改善,特别是在预发性阿尔茨海默病中,这需要进一步调查西的独立效应.
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