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水果摄入量和阿尔茨海默病: 孟德尔随机化的结果

W-Z Liao¹, X-F Zhu, Q Xin

¹Wan-Zhe Liao, Nanshan College of Guangzhou Medical University, Guangzhou, China, E-mail: wanzheliao@outlook.com; Xu-Guang Guo, Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University Guangzhou, China.

The journal of prevention of Alzheimer's disease

|February 20, 2024

概括

干果摄入量显示出与阿尔茨海默氏病 (AD) 风险有显著的因果关系. 然而,在本研究中,新鲜水果的消费没有对AD责任产生类似的因果关系.

科学领域:

营养神经科学营养神经科学
遗传流行病学遗传流行病学

背景情况:

阿尔茨海默氏症 (AD) 是导致痴呆的主要原因,也是全球健康问题.
饮食因素越来越多地被研究出它们在神经退行性疾病病因中的作用.
了解水果摄入量对AD风险的具体影响对于公共卫生建议至关重要.

研究的目的:

调查新鲜水果摄入量和干水果摄入量对阿尔茨海默病 (AD) 的潜在因果关系.
区分各种水果加工方法 (新鲜或干燥) 对AD风险的影响.

主要方法:

使用孟德尔随机化 (MR) 分析与来自英国生物银行和FinnGen.com的全基因组关联研究 (GWAS) 数据.
采用逆方差加权 (IVW),MR-Egger和加权中位数方法来进行可靠的因果推断.
通过视觉检查评估结果的稳定性,异质性和类型分析.

主要成果:

没有发现新鲜水果摄入量和阿尔茨海默病的可能性之间存在因果关系的重要证据 (OR=0.97,P=0.939).
在干果摄入量和AD增加的责任性 (OR=4.09,P<0.001) 之间显示出显著,强大的积极因果关系.
稳定性分析证实没有显著的异质性或质性,支持研究结果的可信性.

结论:

强化证据支持干水果消费对阿尔茨海默氏病病率的积极因果关系.
该研究没有发现证据支持新鲜水果摄入在阿尔茨海默病风险中的因果关系.
这些发现强调了在预防神经退行性疾病的饮食建议中考虑食品加工的重要性.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.摄入水果的摄入量水果的摄入量老龄化健康老龄化健康两个样本的门德尔式随机化

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