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测试雄激素诱导的免疫抑制:环境雄激素作为类固醇免疫相互作用的模型系统

Jorge E López-Pérez¹, Jeffrey M Goessling², Christopher M Murray¹

¹Department of Biological Sciences, Southeastern Louisiana University, Hammond, Louisiana, USA.

Journal of experimental zoology. Part A, Ecological and integrative physiology

|February 20, 2024

概括

雄激素不会抑制鱼的免疫能力. 相反,暴露于雌激素17-α-methyltestosterone增强了获得的免疫反应,这表明鱼具有增强免疫力的作用.

科学领域:

比较免疫学比较免疫学
内分泌学在内分泌学.
类学类学类学类学

背景情况:

荷尔蒙调节生理学是广泛的,但具体的关系,比如生殖腺荷尔蒙和免疫之间的,是争论的.
人们普遍认为雄激素会抑制免疫功能,但缺乏一致的证据.

研究的目的:

为了测试这种假设,雄激素抑制美国鱼 (Alligator mississippiensis) 的免疫能力.
调查雄激素暴露对成长中的鱼的先天性和获得性免疫功能的影响.

主要方法:

发展中的鱼在早期发育过程中暴露于17-α-甲基 (MT),一种非可芳香的雌激素.
通过量化白细胞概况,先天性免疫 (血液溶解-血液凝结) 和在暴露于抗原后获得的免疫 (抗体标位) 来评估免疫功能.

主要成果:

在暴露于雄激素和对照组之间的白细胞比率或比例中没有发现显著差异.
天生的免疫功能在两组之间没有显著差异.
暴露于雌激素 (男性化) 的鱼表现出显著更高的抗体标位,表明增强的获得性幽默免疫力.

结论:

这些发现驳斥了雄激素抑制美国鱼免疫能力的假设.
雄激素可以增强获得的幽默免疫反应,同时对鱼的先天性幽默免疫产生中性作用.

关键词:

获得免疫力获得免疫力生态免疫学生态免疫学破坏内分泌的化合物破坏内分泌的化合物这是先天免疫力.甲基测试的使用方法

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