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截然不同的神经元电路介导肌皮层过敏性在肌缩侧面硬化症中

Nathan Pavey¹, Andrew Hannaford¹, Mehdi van den Bos¹

¹Brain and Nerve Research Centre, Concord Clinical School, The University of Sydney, Concord Hospital, Sydney, NSW 2139, Australia.

Brain : a journal of neurology

|February 20, 2024

概括

肌肉皮层过度兴奋性在肌缩侧面硬化症 (ALS) 中与改变的运动皮层功能有关. 跨磁刺激 (TMS) 显示抑制降低和促进增加,特别是在特定的线圈方向,影响皮质脊髓通道.

科学领域:

神经科学是一个神经科学.
神经学神经学
生理学生理学生理学

背景情况:

皮层过敏性是肌缩侧面硬化症 (ALS) 病理生理学的关键特征.
这种过度兴奋性源于大脑中抑制性和促进性内神经元过程的复杂相互作用.
跨磁刺激 (TMS) 的进步允许详细调查运动皮层变化.

研究的目的:

为了研究ALS患者的运动皮层刺激性的改变,使用值追踪TMS.
探索特定的内神经回路功能障碍和ALS中的认知功能之间的关系.
确定不同的TMS线圈方向如何揭示ALS皮质功能障碍的不同方面.

主要方法:

在29名ALS患者和健康对照中,使用值追踪TMS来评估短间隔内皮抑制 (SICI) 和短间隔内皮促进 (SICF).
改变了TMS线圈的方向 (后部-前部,侧部-中部,前部-后部),以探测不同的内核电路.
评估了皮层运动功能和认知,并使用爱丁堡认知和行为ALS屏幕进行认知评估.

主要成果:

与对照人群相比,ALS患者的平均SICI显著降低,后部-前部 (P=0.044) 和侧部-中部 (P=0.005) 卷轴方向.
平均SICF在ALS患者中显著增加,后部-前部 (P=0.035) 和侧部-中部 (P<0.001) 方向.
在降低的SICI (后部-前部) 和较低的认知分数 (Rho=0.389,P=0.037) 之间发现了相关性.

结论:

特定内神经回路的功能障碍,特别是那些由后向前和侧向中间TMS激活的功能障碍,有助于ALS中的皮质过敏.
这些发现凸显了ALS病理生理学中抑制和促进途径之间的复杂相互作用.
了解这些电路特定机制可能会导致针对ALS的向治疗策略.

关键词:

这是ALS的亚型.在SICF中,我们可以看到.西西里岛 (SICI)皮层刺激性的皮层刺激性.内部神经元内部神经元临床疾病发病的地区.

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