在患有乳腺甲状腺癌的青少年中,甲状腺激素撤回后急性损伤
Yavuz Özer1, Rüveyda Gülmez2, Hande Turan1
1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Pediatric Endocrinology, Istanbul, Turkey.
Journal of clinical research in pediatric endocrinology
|February 20, 2024
概括
在放射性治疗之前的甲状腺激素停用可能会导致急性损伤和状甲状腺癌患者的肌酸激酶升高. 在甲状腺切除术后,监测功能和预防脱水是至关重要的.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
背景情况:
- 乳头甲状腺癌 (PTC) 的治疗通常包括全甲状腺切除术和放射性治疗.
- 甲状腺激素撤销 (THW) 是放射性给药前的一个必要步骤,以最大限度地吸收放射性.
- 潜在的THW并发症,如急性损伤 (AKI) 和增加的肌酸激酶 (CK),尚未得到广泛认可.
研究的目的:
- 报告一个PTC患者的病例,该患者在THW后发展了AKI和升高的CK.
- 突出监测THW的PTC患者功能和CK水平的重要性.
- 强调需要采取预防措施,防止在THW期间脱水.
主要方法:
- 一个12岁的女性患有PTC的案例报告.
- 检查实验室检测结果,包括血清肌素,阿斯巴酸胺转移酶,CK,铁胺和自由T4水平.
- 临床评估和治疗反应,包括静脉注射水和levothyroxine.
主要成果:
- 患者在THW和放射性治疗后出现了腿部疼痛,血清肌素升高 (1.53 mg/dL) 和CK (3451 IU/L).
- 甲状腺激素水平显著升高 (>100μIU/ml),自由T4降低 (0.05 ng/dL).
- 血清肌素和CK水平在及时静脉注射水分和开始Levothyroxine治疗后正常化.
结论:
- 接受THW的PTC患者有发展AKI和升高CK的风险.
- 在THW后的PTC患者中,应该定期评估功能和CK水平.
- 预防脱水是减轻这些并发症风险的关键措施.
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