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Updated: Jul 2, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

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mRNA PROTACs:用于高效率的向蛋白质降解的工程 PROTACs

Xiaoqi Xue1, Chen Zhang1, Xiaolin Li1

  • 1State Key Laboratory of Chemical Oncogenomics Institute of Biopharmaceutical and Health Engineering Shenzhen International Graduate School, Tsinghua University Shenzhen China.

MedComm
|February 20, 2024
PubMed
概括

我们开发了针对mRNA蛋白解的嵌合体 (mPROTACs) 来降解标蛋白质. 与类PROTAC相比,这些mPROTACs在降解癌症蛋白质和抑制细胞增殖方面表现出更强的有效性,从而在体内导致显著的瘤回归.

关键词:
有针对性的蛋白质降解 (TPD)在体外转录的mRNA (IVT-mRNA)它们是mRNARNA.酸蛋白解酶向的嵌合体.针对蛋白质溶解的仿真体 (PROTAC)

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