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治疗因素和基于生物材料的输送工具用于退行性脊椎间盘修复

Haoyang Song¹, Chuan Guo¹, Ye Wu¹

¹Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Frontiers in cell and developmental biology

|February 20, 2024

概括

椎间盘退化 (IDD) 导致腰部疼痛 (LBP). 新的研究探索生物材料和生物活性物质,以有效治疗和潜在地逆转IDD进展.

科学领域:

生物医学工程生物医学工程
再生医学是一种再生医学.
整形外科整形外科整形外科

背景情况:

椎间盘退化 (IDD) 是腰部疼痛 (LBP) 的首要原因,导致全球健康和经济负担显著.
目前IDD的治疗方法只能缓解症状或延迟疾病的进展,这凸显了有效的再生策略的必要性.
现有治疗方法的局限性凸显出迫切需要新的方法来预防或逆转IDD.

研究的目的:

提供关于椎间盘退化 (IDD) 过程的概述.
研究用于IDD治疗的生物材料和生物活性物质的最新进展.
探索这些新治疗策略的潜在机制.

主要方法:

关于椎间盘退化 (IDD) 和其治疗的当前文献的综述.
分析各种生物活性物质,包括小分子药物,核酸和细胞疗法.
检查各种生物材料输送系统,如纳米微粒,微球和水凝.

主要成果:

生物材料集成的生物活性物质在IDD的临床前研究中显示出有希望的结果.
不同的生物活性剂具有独特的磁盘修复能力.
多种生物材料输送系统提供了不同的生物和释放特征,适合IDD治疗.

结论:

先进的生物材料和向生物活性物质的组合为有效的椎间盘退化 (IDD) 治疗提供了一个有希望的途径.
进一步研究机制和传递系统对于临床翻译至关重要.
这些创新方法有可能从根本上改变与IDD相关的腰部疼痛的管理.

关键词:

生物工程治疗学生物工程治疗学生物材料是一种生物材料.椎间盘之间的椎间盘.椎间盘退化椎间盘退化治疗因素是治疗因素.

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