认知储备以及老年人手术后神经认知障碍的风险
Friedrich Borchers1, Miriam Rumpel2, Jochen Laubrock2
1Department of Anesthesiology and Intensive Care Medicine (CCM, CVK), Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Frontiers in aging neuroscience
|February 20, 2024
概括
更高的智商可能会降低接受手术的老年人患术后妄想症 (POD) 的风险. 认知储备 (CR) 标志物,包括智商,教育和职业,被检查了它们与POD和术后认知功能障碍 (POCD) 的关联.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 外科手术的结果
背景情况:
- 手术后的神经认知障碍 (PND),包括手术后痴呆症 (POD) 和手术后认知功能障碍 (POCD),在手术后很常见.
- 认知储备 (CR) 影响认知健康和对神经病理的恢复能力的个体差异.
- 智商,教育和职业等因素被认为是CR的代理因素.
研究的目的:
- 研究认知储备 (CR) 与POD和POCD在接受选择性手术的老年患者的发病率之间的关联.
- 确定特定的CR标志物 (智商,教育,职业复杂性) 是否预测PND的风险.
主要方法:
- 研究了65岁及以上的713名接受选择性手术的患者队列.
- 病前智商 (词汇),职业复杂性 (DOT) 和教育水平 (ISCED) 被用作CR代理.
- 对年龄,性别,抑郁症,手术地点,生活方式和血管因素进行控制的回归模型.
主要成果:
- 较高的病前智商与较低的发展POD的几率显著相关.
- 其他CR标记 (教育,职业) 和POD之间没有发现显著的关联.
- 没有一个研究的CR标志物显示出与POCD有显著的关联.
结论:
- 较高的智商可能作为老年手术患者对POD的保护因素,使风险分层成为可能.
- 这一发现可以为POD预防和早期检测的战略提供信息.
- 需要进一步的研究来了解本研究中CR标志物和POCD之间缺乏关联.
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