在健康的阿富汗人群中建立血液参数的参考间隔
Najia Sherzay1,2,3, Ziauddin Azimi1,2, Siti Hamimah Sheikh Abdul Kadir1,4
1Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Cawangan Selangor, Sungai Buloh, Selangor, 47000, Malaysia.
Journal of blood medicine
|February 20, 2024
概括
阿富汗喀布尔的血液学参考值与全球标准不同. 这项研究发现,阿富汗男性的血红蛋白和血红素水平显著更高,这表明需要特定人口的参考间隔.
科学领域:
- 临床血液学 临床血液学
- 人口健康 人口健康
- 参考价值的确定方法
背景情况:
- 确定准确的血液学参考值对于诊断和管理各种健康状况至关重要.
- 现有的参考间隔可能不准确地反映特定种族或地理群体的生理特征.
研究的目的:
- 在阿富汗喀布尔的健康成年居民中验证和建立关键血液学参数的参考值.
- 为了比较研究人口中男性和女性之间的这些参考值.
主要方法:
- 一项涉及喀布尔大学166名18-45岁男性和125名女性的横截面研究.
- 参与者使用问卷和血清费里和维生素B12水平的评估进行了查,以排除具有潜在混因素的个人.
- 分析了血液学参数,并使用非参数方法确定了参考范围.
主要成果:
- 发现血红蛋白和血红素的参考间隔在男性中明显高于女性 (p<0.05).
- 血红蛋白参考间隔:4.5-6.3g/dL (男性) 和3.66-5.67g/dL (女性). 血红蛋白参考间隔:4.5-6.3g/dL (男性) 和3.66-5.67g/dL (女性).
- 血红素参考间隔:36.23-55.93% (男性) 和30.20-53.86% (女性).
- 红细胞计数参考间隔在两性之间没有发现显著差异.
结论:
- 这些发现表明,目前广泛使用的血液学参考间隔可能不适合阿富汗人群.
- 建议在阿富汗进行临床使用,对血红蛋白和血红素的经过修订,人群特异性参考值.
- 这项研究强调了当地数据对于准确的健康评估的重要性.
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