甲状腺功能低下症是欧洲人口与年龄相关的白内障风险的因果决定因素:孟德尔的随机化研究
Shu Liu1, Qi Sun2, Qingwei Gu2
1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Frontiers in endocrinology
|February 20, 2024
概括
甲状腺功能低下症显著增加与年龄相关的白内障 (ARC) 的风险. 这项研究发现了因果关系,表明甲状腺健康对于预防ARC至关重要. 需要对这种联系进行进一步的研究.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 与年龄相关的白内障 (ARC) 是全球视力障碍的主要原因.
- 甲状腺功能障碍,包括甲状腺功能障碍和甲状腺功能障碍,影响着相当一部分人群.
- 甲状腺功能障碍和ARC风险之间的潜在因果关系仍然不完全理解.
研究的目的:
- 调查甲状腺功能障碍对欧洲人口患年龄相关白内障 (ARC) 的风险的因果关系.
- 在ARC病因学中区分甲状腺功能低下症,甲状腺功能过高症和循环甲状腺激素水平 (自由甲状腺素和甲状腺激素) 的因果作用.
主要方法:
- 采用了两个样本的门德尔随机化 (MR) 研究设计.
- 与甲状腺功能低下症,甲状腺功能过高症,自由甲状腺素 (fT4) 和甲状腺激素 (TSH) 相关的遗传变异被用作仪器变量.
- 来自欧洲大型队列的全基因组关联研究数据被用于暴露和结果 (ARC).
主要成果:
- 基因预测的甲状腺功能低下症与ARC风险增加有显著的积极因果关系 (OR = 2.501,P = 0.004).
- 对于甲状腺功能障碍,FT4或TSH对ARC风险没有显著的因果关系 (P>0.05).
- 灵敏度分析证实了研究结果的可靠性,并排除了横向类和反向因果关系.
结论:
- 甲状腺功能低下症被确定为与年龄相关的白内障风险的重要因果决定因素.
- 这些发现凸显了甲状腺功能在眼睛健康中的重要性,并强调了需要监测甲状腺状况的人有风险的ARC.
相关概念视频
Aging
51
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
51
Mutations
82.2K
Overview
82.2K
Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
Genetic Lingo
102.8K
Overview
102.8K
Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K


