血连接组织生长因子水平与左心室扩张性功能障碍的关联在明显甲状腺功能过高的患者中
Huan Li1,2, Yahui Ren3, Linfang Wang4
1Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in endocrinology
|February 20, 2024
概括
结合性组织生长因子 (CTGF) 水平升高与甲状腺功能过高患者的左心室 (LV) 扩张功能障碍有关. 血CTGF可以作为诊断这种疾病的辅助生物标志物.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 甲状腺学 甲状腺学
背景情况:
- 左心室 (LV) 舒张功能障碍预测心血管事件.
- 早期发现和管理对于改善结果至关重要.
- 目前用于评估 LV 扩张功能障碍风险的生物标志物有限.
研究的目的:
- 调查血连接组织生长因子 (CTGF) 水平与 LV 扩张功能障碍的风险之间的关联.
- 评估血CTGF的有效性,作为LV透气功能障碍的诊断标志物.
主要方法:
- 包括169名患有明显甲状腺功能障碍的患者.
- 评估了 LV 透静功能,并将患者分为正常和功能障碍组.
- 分析了临床,生化,甲状腺和心声学参数,包括血CTGF水平.
主要成果:
- 患有 LV 扩张功能障碍的患者表现出更高的年龄,BMI 和高血压发病率,以及较低的心率,血清白蛋白和eGFR.
- 血CTGF度在LV腹筋功能障碍组显著更高 (8.290 ng/ml对比7.026 ng/ml).
- 较高的CTGF四分位数与增加的LV透气功能障碍的几率相关,血CTGF的AUC为0.659.
结论:
- 流通的血CTGF水平在患有LV透气功能障碍的患者中显著升高.
- 血CTGF被确定为LV透气功能障碍的独立风险因素.
- 血CTGF可能为甲状腺功能障碍患者的 LV 扩张性功能障碍提供辅助诊断价值,可能会超过血清BNP.
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