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在体内,使用芯片上的尖端摄像机对微血管输血进行激光光斑对比成像

Lukas Markwalder¹, Rodney Gush², Faisel Khan¹

¹Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital & Medical School, DD1 9SY Dundee, UK.

|February 20, 2024

概括

一个微型的芯片上的尖端摄像头使手持激光光斑对比成像 (LSCI) 实现实时血液 perfusion 评估. 这项技术提供了与标准设备相匹配的结果,将LSCI的应用扩展到内部器官和组织.

科学领域:

生物医学光学生物医学光学
医学成像技术医学成像技术
生理测量生理测量

背景情况:

激光光斑对比成像 (LSCI) 对于非侵入性实时组织 perfusion 评估至关重要.
目前的LSCI设备是重的,限制了它们的使用到外围皮肤应用.
对于成像内部器官和组织,需要LSCI仪器的小型化.

研究的目的:

为了描述一种新的1mm2芯片上的尖端摄像机,用于激光斑点对比成像 (LSCI) 的血液 perfusion.
为了评估小型LSCI系统与高规格参考摄像头相比的性能.
为了在各种模型中展示芯片上尖端摄像机用于*in vivo* perfusion 成像的可行性.

主要方法:

一个专门的光学设置被设计为对比芯片上的尖端摄像头与LSCI的参考摄像头 (GS3).
使用校准标准和流量幻影来评估性能.
摄像机被用于*in vivo*小动物模型中的胎盘 perfusion 评估和人类指尖 perfusion 研究.

主要成果:

芯片上的尖端摄像机显示了与参考摄像机相比较的LSCI性能.
该系统成功地捕获了组织 perfusion 的广场 *in vivo* LSCI.
物理血流变化得到了准确的测量,与标准LSCI仪器可比.

结论:

微型芯片上的尖端摄像头是用于广场,*in vivo*LSCI的可行工具.
这项技术使手持仪器能够准确地绘制内部器官和组织的斑点 perfusion 地图.
开发的LSCI系统将输液成像的临床适用性扩展到外围部位之外.

关键词:

生物设备是一种生物设备.生物工程是生物工程.设备设备设备材料科学是一种材料科学.医疗器械医疗器械医疗器械

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