前列腺癌积极监测的男性的丸激素治疗的瘤结果:基于人口的分析
Elie Kaplan-Marans1, Tenny R Zhang2, Jim C Hu2,3
1Division of Urology, Maimonides Medical Center, New York, NY, USA.
European urology open science
|February 20, 2024
概括
对于前列腺癌的积极监测中的男性,丸激素治疗没有增加癌症进展或死亡的风险. 这项研究在接受丸激素的患者中没有发现任何不良瘤结果.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
背景情况:
- 在积极监测下,前列腺癌患者的丸激素治疗对瘤风险的证据有限.
- 积极监测是低风险前列腺癌的常见管理策略.
研究的目的:
- 评估丸激素治疗对前列腺癌患者在积极监测下管理的瘤结局的影响.
- 评估丸激素治疗与这种患者群体的疾病进展或死亡率之间的关联.
主要方法:
- 对监测,流行病学和最终结果 (SEER) -医疗保险相关数据 (2008-2017) 的回顾性分析.
- 在积极监测中确定了前列腺癌的男性,比较那些接受丸激素 (n=167) 和没有丸激素 (n=6658) 的男性.
- 分析的结果包括转换到积极治疗,前列腺癌特异性死亡率和使用Cox比例风险回归的整体死亡率.
主要成果:
- 在和非组之间没有观察到转换到活性治疗的显著差异 (HR 0.66,95% CI 0.46-0.97;p=0.033).
- 丸激素组中没有发生前列腺癌特异性死亡,而无丸激素组的死亡人数为39 (0.6%).
- 丸激素治疗与整体死亡率的增加无关 (HR1.02,95% CI 0.68-1.53;p>0.9).
结论:
- 在积极监测下,丸激素治疗似乎不会增加前列腺癌男性的疾病进展或死亡风险.
- 这项以人口为基础的研究提供了初步证据,表明在这种情况下丸激素治疗的安全性.
- 需要进一步的前性研究来证实这些发现并制定最终的临床建议.
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