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含有低密度Babesia microti的输血血液的传播风险评估

Yuchun Cai^1,2, Bin Xu^1,2, Xiufeng Liu³

¹Laboratory of Parasite and Vector Biology, Ministry of Public Health, World Health Organization (WHO) Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, China.

Frontiers in cellular and infection microbiology

|February 20, 2024

概括

输血传染的宝贝菌病风险是显著的,即使在低的宝贝菌微型 (B. microti) 水平. 这项研究证实低密度的B. microti可以感染接收者,强调了强制性血液查的必要性.

科学领域:

寄生虫学的寄生虫学
传染性疾病传染性疾病
输血医学输血医学

背景情况:

贝贝西亚是一种感染红细胞的虫寄生虫,具有输血传播的贝贝西病的风险.
在捐献血液中检测低密度Babesia microti (B. microti) 仍然是一个挑战,其公共卫生影响尚不清楚.

研究的目的:

为了确定血液中B. microti的较低检测极限.
评估与低密度B. microti感染相关的输血传播风险.

主要方法:

使用不同的B. microti密度建立了受感染的小鼠模型.
使用显微镜,嵌套PCR和ELISA来监测感染状态.
用B. microtiDNA和受感染的血液样本确定了嵌套PCR检测极限.

主要成果:

嵌套PCR检测到B. microtiDNA在3 fg和寄生虫密度低至5.48寄生虫/μL.
输血的血液与极低的B. microti密度成功感染受体小鼠.
感染小鼠的抗体水平在感染后60天达到峰值.

结论:

即使在全血中B. microti的密度极低,也会造成大量的输血传播风险.
为保护公共健康,建议在献血和输血之前强制进行贝贝西亚查.

关键词:

贝贝西亚微型检测极限的检测极限人类婴儿乳腺炎 (Human Babesiosis) 是一种输血传输输输输输输输输输输输输风险的传播风险的传播.

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