在COVID-19患者中治疗严重喘的生物药物的临床特征
Takanori Numata1, Keitaro Okuda1, Hanae Miyagawa1
1Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
The journal of allergy and clinical immunology. Global
|February 20, 2024
概括
在Omicron波期间,严重喘患者的COVID-19严重程度取决于疫苗接种状态. 喘恶化与基线喘控制和疫苗接种有关,而不是生物药物.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 有限的数据存在于冠状病毒疾病2019 (COVID-19) 临床特征在严重喘 (SA) 患者的生物药物.
- 了解COVID-19对以生物制剂治疗的南非患者的影响至关重要.
研究的目的:
- 在接受生物治疗的严重喘患者中调查COVID-19的临床特征.
- 在Omicron疫情期间分析COVID-19和严重喘严重程度之间的相互作用.
主要方法:
- 对99名接受生物治疗的严重喘患者的回顾性研究 (2022年1月至2023年2月).
- 收集了关于COVID-19和喘恶化严重程度,疫苗接种状态以及基线喘控制测试 (ACT) 成绩的数据.
主要成果:
- 在26/29名患者中,COVID-19是轻度的;3人患有中度疾病. 较高的疫苗接种人数与较轻的COVID-19相关 (P=.03).
- 喘恶化是轻微的 (9) 或中度的 (7). 恶化的严重程度与基线ACT分数相关 (P=.004).
- 较低的疫苗接种人数是COVID-19进展的风险因素 (OR 0.64,P=.006).
结论:
- 在奥米克朗疫情期间,SA患者的COVID-19发病和严重程度与疫苗接种状态有关.
- 喘恶化的严重程度与基线ACT得分和接种疫苗的数量相关,独立于生物使用.
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