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Updated: Aug 8, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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在唐氏综合征回归障碍中,与免疫治疗反应相关的神经影像异常

Jonathan D Santoro1,2, Mellad M Khoshnood1, Saba Jafarpour1

  • 1Division of Neuroimmunology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA.

Annals of clinical and translational neurology
|February 20, 2024
PubMed
概括

神经成像异常,特别是SWI和T2/FLAIR信号,在唐氏综合征回归障碍 (DSRD) 中更为普遍. 这些发现预测DSRD患者对免疫治疗的反应更好.

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...