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皮质热素释放激素对健康志愿者的胃电活动和感觉运动功能的影响:双盲交叉研究

I-Hsuan Huang^1,2, Jolien Schol¹, Stefan Calder³

¹Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.

American journal of physiology. Gastrointestinal and liver physiology

|February 20, 2024

概括

压力激素皮质激素释放激素 (CRH) 加快胃排空,增加健康个体的症状. CRH影响肠-大脑相互作用,但不影响胃敏感性或适应性.

科学领域:

神经胃肠病学神经胃肠病学
压力生理学压力生理学
胃肠道生理学胃肠道生理学

背景情况:

生物心理社会因素和压力显著影响肠-大脑相互作用障碍 (DGBI) 和胃肠道症状.
将压力与肠道的病理生理变化联系在一起的机制仍然不完全理解.
皮质otropin释放激素 (CRH),是压力反应的关键调节者,影响多个器官系统.

研究的目的:

为了研究外围CRH输液对与饮食相关的胃肠道症状的影响.
评估CRH对健康志愿者的胃电活动和感官运动功能的影响.
阐明CRH在调解压力诱导的胃肠道变化的作用.

主要方法:

一项随机,双盲,安慰剂控制,交叉研究,涉及健康志愿者.
使用身体表面胃映射 (BSGM) 评估胃空化 (GE) 和胃肌电活动.
评估胃敏感性和适应性通过胃气压研究.

主要成果:

输入CRH显著降低了胃排空半时,并增加了胃电活动幅度.
唾液皮质醇水平和食后症状严重程度在CRH给药后显著升高.
在不适值,胃顺应或CRH和安慰剂条件之间的适应方面没有发现显著差异.

结论:

周围的CRH输液加速胃排空,并增强健康个体的食后胃反应.
施用CRH导致症状严重程度增加,突出其在与压力相关的消化不良症状中的作用.
CRH似乎不会改变胃敏感性或食适应性,这表明特定的途径介导其对肠道运动性和症状的影响.

关键词:

身体表面胃映射胃映射皮质热素释放激素的皮质热素释放激素胃机动性的胃机动性胃肌电活动胃肌电活动胃的感觉运动功能

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