支气管挑测试的阳性是否与血中乙氨基酸细胞计数和切断值有关?
1Immunology and Allergy Clinic, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey. metin.keren1@saglik.gov.tr.
European review for medical and pharmacological sciences
|February 20, 2024
概括
这项研究发现,更高的血中乙氨基酸细胞计数与喘患者的阳性支气管挑测试 (BPT) 有关. 226个细胞/μl或更高的数量可能有助于BPT规划和喘诊断.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 诊断生物标志物 诊断生物标志物
背景情况:
- 喘涉及呼吸道过敏反应和慢性炎症,其中氨基球起着关键作用.
- 支气管挑测试 (BPT) 用于评估气道过度响应.
- 血红蛋白细胞数量与BPT结果之间的关系需要进一步澄清.
研究的目的:
- 在喘患者中调查BPT结果与血中乙氨基酸细胞计数之间的关联.
- 为了确定与BPT阳性相关的血中乙氨基酸细胞计数的潜在切断值.
主要方法:
- 对246名喘患者进行了回顾性分析,这些患者接受了甲胆BPT.
- 根据BPT阳性和阴性,患者被分类.
- 在BPT阳性和BPT阴性组之间比较了血中乙氨基酸细胞计数.
主要成果:
- 在36.6%的患者中,BPT呈阳性,在63.4%的患者中呈阴性.
- 与BPT阴性患者 (119细胞/μl) 相比,BPT阳性患者 (135细胞/μl) 的血中乙氨基酸细胞数量显著更高.
- 确定了≥226个细胞/μl的血红素切割值,具有30.0%的灵敏度和87.7%的特异性.
结论:
- 在喘中,BPT阳性与血中异氨基细胞数量升高有关.
- 血中乙氨基酸细胞计数的≥226细胞/μl的确定的切断值可能有助于BPT规划和喘诊断.
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