天然化合物二素通过其高亲和力结合B细胞淋巴瘤-2准多种癌症途径
Shweta Gulia1, Prakash Chandra1, Asmita Das1
1Delhi Technological University, Main Bawana Road, Delhi, 110042, India.
Current computer-aided drug design
|February 20, 2024
概括
这项研究确定了癌症途径中常见的基因,并发现迪奥辛降低了许多癌症中的关键蛋白Bcl-2的调节. 迪奥辛显示出作为一种天然抑制剂的潜力,向多种癌症途径.
科学领域:
- 在瘤学瘤学.
- 计算生物学 计算生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 癌症的进展涉及复杂的生物过程,如上皮层-介质细胞过渡 (EMT),自,细胞亡,阿诺基斯和转移.
- 在这些途径中识别共同的基因对于开发向疗法至关重要.
- 在各种癌症中,Bcl-2经常过度表达,这使得它成为一个重要的治疗点.
研究的目的:
- 为了确定涉及EMT,自,亡,阿诺基斯和转移的常见基因.
- 在不同类型的癌症中分析Bcl-2表达水平.
- 为发现一种强大的天然化合物抑制剂Bcl-2.
主要方法:
- 用基因表达分析和通路分析来识别常见的基因.
- 用分子对接和分子动力学模拟来选天然化合物的Bcl-2抑制.
- 对已识别的化合物Dioscin进行了差异基因表达分析 (GEO2R).
主要成果:
- 在研究的癌症途径中发现了四个常见基因 (Bcl-2,Bax,BIRC3,CHUK).
- 发现Bcl-2在急性髓性白血病,扩散性大B细胞淋巴瘤和胸腺瘤中表达过度.
- 迪奥辛对Bcl-2表现出显著的结合亲和力,降低了Bcl-2,BIRC3和CHUK的调节,同时提高了Bax.
结论:
- 迪奥辛具有作为一种向Bcl-2结合部位的蛋白质抑制剂的潜力.
- 迪奥辛与Bcl-2相互作用并调节关键癌症相关基因的能力表明其治疗承诺.
- 迪奥辛可以作为一种有价值的天然化合物,通过单个分子标来准多种癌症途径.
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:31The Intrinsic Apoptotic Pathway
6.5K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.5K
02:34Inhibition of Cdk Activity
4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:25Selectins
3.3K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.3K
01:27Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524