风是否会增加患骨髓炎和败血性关节炎的风险? 一个综合电子健康记录数据研究的综合数据
Monish S Lavu1, Chloe Van Dorn1, Lukas Bobak1
1Department of Orthopaedics, Case Western Reserve University School of Medicine.
Journal of pediatric orthopedics. Part B
|February 20, 2024
概括
患有的儿科患者患骨髓炎和败血性关节炎的风险明显更高. 这项研究强调了对这些严重的肌肉骨感染的临床警的必要性.
科学领域:
- 儿科整形外科 儿科整形外科
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- Rickets,一个由骨软化特征的条件,可以有各种潜在的原因和潜在的并发症.
- 肌肉骨感染,如骨质炎和败血性关节炎,是儿童的严重疾病,需要及时诊断和治疗.
研究的目的:
- 为了确定患有骨髓炎和败血性关节炎的患病率,在被诊断为患有恶心病的儿科患者中.
- 为了比较这些感染的风险,儿童患有与一般的儿科人口.
主要方法:
- 使用TriNetX分析网络进行的回顾性队列研究,包括超过1.05亿美国患者的非身份电子健康记录.
- 确定了儿科患者 (≤18岁) 患有拉基茨诊断 (ICD-10-CM代码),以及没有拉基茨的对照队列.
- 骨髓炎和败血性关节炎诊断的患病率和相对风险计算了两个队列.
主要成果:
- 在7337名患有病的儿科患者中,1.31%患有骨髓炎,0.38%患有败血性关节炎.
- 相比之下,在17,240,604名没有的儿科患者中,0.10%患有骨髓炎,0.05%患有败血性关节炎.
- 患有的儿科患者的骨髓炎相对风险增加了13.27倍,性关节炎的相对风险增加了7.72倍.
结论:
- 患有拉基茨的儿童患者与没有拉基茨的同龄人相比,患有骨髓炎和败血性关节炎的相对风险要高得多.
- 这些发现强调了提高临床意识和警对于被诊断为患有病的儿童肌肉骨感染的关键重要性.
- 这项研究是第一个在大型儿科队列中调查病与这些特定的骨关节感染之间的关联.
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