通过辅助生殖技术,父亲肥胖和子女心脏代谢变化之间的关联
Bingqian Zhang1,2,3,4,5,6,7,8,9, Miaomiao Ban1,3,4,5,6,7,8,9, Xiaojing Chen1,3,4,5,6,7,8,9
1Children and Reproductive Health, Institute of Women, The Second Hospital, Shandong University, Shandong, 250012, China.
父亲肥胖会对通过辅助生殖技术 (ART) 怀孕的孩子产生负面影响,增加他们患肥胖和胰岛素抵抗的风险. 后代的体重指数 (BMI) 在这些不良的心脏代谢变化中起着关键作用.
科学领域:
- 生殖医学 生殖医学
- 儿科内分泌学 儿科内分泌学
- 代谢健康 代谢健康
背景情况:
- 辅助生殖技术 (ART) 和父亲肥胖症独立地与后代的不良心脏代谢结果有关.
- 父亲肥胖和ART对后代心脏代谢健康的综合影响仍然不完全理解.
研究的目的:
- 研究通过ART怀孕后代的心脏代谢特征,特别关注父亲肥胖的影响.
- 为了澄清父亲肥胖和ART怀孕儿童心脏代谢变化之间的关联.
主要方法:
- 追溯队列研究涉及2890个单独的ART受孕儿童,年龄在4-10岁之间.
- 对体重指数 (BMI),血压,胰岛素耐药性 (HOMA-IR) 和脂质资料的年龄和性别特定的z-score进行分析.
- 多变量回归和调解分析,以评估父亲的BMI类别和后代的BMI的影响.
主要成果:
- 父亲肥胖与子女BMIz-score (0.53),静脉血压z-score (0.21) 和胰岛素抵抗z-score (0.31) 的增加显著相关.
- 后代的BMI被确定为一个显著的调解者,可能解释了57.48%至94.75%的父亲肥胖和不良心脏代谢结果之间的关联.
- 超重的父亲也增加了后代的BMI和血压,而体重不足的父亲降低了后代的BMI.
结论:
- 父亲肥胖与ART受孕后代的不良心脏代谢特征有关.
- 后代的BMI是关键的调解者,将父亲的肥胖与通过ART怀孕的儿童的代谢健康受损联系起来.
- 这些发现强调了父亲体重状况在辅助生殖和后代健康的背景下的重要性.
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